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鉤藤堿

分析標(biāo)準(zhǔn)品,HPLC≥98%

Rhyncholphylline

CAS號：76-66-4

分子式：C22H28N2O4

分子量：384.47

MDL：MFCD00221748

產(chǎn)品介紹

熔點：216℃

沸點：560.8 ℃ at 760 mmHg

比旋光度：D13 -14.7° (c = 2.5 in chloroform)

外觀：白色結(jié)晶

溶解性：溶于氯仿、丙tong、乙醇、苯，微溶于乙mi和醋酸乙酯，幾乎不溶于石油醚。

儲存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(28篇)

28. [IF=6] Tao Hu et al."Haploid-Phased Chromosomal Telomere-to-Telomere Genome Assembly of Medicinal Plant Uncaria rhynchophylla Dissects Genetic Controls on the Biosynthesis of Bioactive Alkaloids."PLANT CELL AND ENVIRONMENT.2024 Nov;:

27. [IF=6.9] Lei Panpan et al."Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions."ARCHIVES OF PHARMACAL RESEARCH.2024 Dec;:1-13

26. [IF=6.8] Lin Lin et al."Rhynchophylline as an agonist of sirtuin 3 ameliorates endothelial dysfunction via antagonizing mitochondrial damage of endothelial progenitor cells."BRITISH JOURNAL OF PHARMACOLOGY.2025 Mar;:

25. [IF=1.3] Yongzhou Yu et al."Integrated UPLC-MS and multivariate data processing approach to explore the chemical components of Uncaria rhynchophylla and its absorbed components in rats following oral adminstration."JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNO

24. [IF=3.024] Xuan Yu et al."An innovative extraction strategy for herbal medicine by adopting p-sulphonatocalix[6]/[8]arenes."PHYTOCHEMICAL ANALYSIS

23. [IF=5.811] Liu  Jiao et al."Rhynchophylline Regulates Calcium Homeostasis by Antagonizing Ryanodine Receptor 2 Phosphorylation to Improve Diabetic Cardiomyopathy."Frontiers in Pharmacology. 2022 Apr;0:1375

22. [IF=6.529] Lingling Xie et al."Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway."Biomed Pharmacother. 2022 Feb;146:112607

21. [IF=2.649] Long Hongyan et al."Rhynchophyllin attenuates neuroinflammation in Tourette syndrome rats via JAK2/STAT3 and NF‐κB pathways."Environ Toxicol. 2019 Oct;34(10):1114-1120

20. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

19. [IF=3.935] Wenwen Huang et al."Rapid discovery of potentially vasodilative compounds from Uncaria by UHPLC/Q-Orbitrap-MS based metabolomics and correlation analysis."J Pharmaceut Biomed. 2021 Nov;206:114384

18. [IF=3.996] Jiang  Pan et al."Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation."Neurochem Res. 2021 Sep;46(9):2439-2450

17. [IF=4.759] Keyu Feng et al."Configuration of the ion exchange chromatography, hydrophilic interaction chromatography, and reversed-phase chromatography as off-line three-dimensional chromatography coupled with high-resolution quadrupole-Orbitrap mass spectrometry fo

16. [IF=1.908] Xin  Wang et al."Stereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography–tandem mass spectrometry."Xenobiotica. 2017;47(6):479-487

15. [IF=3.935] Shuanglu Xie et al."Systematic identification and quantification of tetracyclic monoterpenoid oxindole alkaloids in Uncaria rhynchophylla and their fragmentations in Q-TOF-MS spectra."J Pharmaceut Biomed. 2013 Jul;81-82:56

14.  鄧向濤,張文周,張智強.鉤藤堿納米混懸劑緩釋片制備、優(yōu)化與體外釋放評價[J].中草藥,2020,51(20):5128-5136.

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12.  郭曉敏, 黃寶媛, 曾常青. 鉤藤生物堿提取物及其單體逆轉(zhuǎn)HepG2/ADM細(xì)胞耐藥活性的篩選[J]. 廣東藥學(xué)院學(xué)報, 2018, 034(004):447-451.

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10.  劉明, 王慧森, 李更生. 春花降壓片的質(zhì)量標(biāo)準(zhǔn)研究[J]. 西北藥學(xué)雜志, 2020, v.35(03):9-12.

9.  張媛媛  曾慧婷  陳超 等. 以離子液體為流動相添加劑的HPLC法分離并測定鉤藤中鉤藤堿和異鉤藤堿的含量[J]. 中國藥房  2019  v.30;No.663(21):77-82.

8.  龍國友  王美  孫剛. HPLC法測定安樂片中鉤藤堿和異鉤藤堿的含量[J]. 中國藥品標(biāo)準(zhǔn)  2017(4).

7.  李素珍, 唐振祥, 吳衛(wèi). 鉤藤堿脂質(zhì)體的制備及釋放度研究[J]. 中華中醫(yī)藥雜志, 2013, 028(012):3730-3732.

6.  趙興業(yè), 王穎慧, 崔曉鴿,等. 鉤藤堿雙層滲透泵控釋片的制備及處方優(yōu)化[J]. 中成藥, 2020, v.42(05):17-21.

5.  徐有偉, 黃真, 周洪雷,等. 藤菔降壓片質(zhì)量控制研究[J]. 中藥新藥與臨床藥理, 2015, 026(005):690-694.

4.  黃真, 周洪雷, 李運倫,等. 藤菔降壓片指紋圖譜評價體系研究[J]. 遼寧中醫(yī)雜志, 2014, 041(006):1251-1253.

3.  閆瑞, 李凌軍, 李順. 天鉤降壓膠囊中鉤藤堿大鼠體內(nèi)藥動學(xué)研究[J]. 山東中醫(yī)藥大學(xué)學(xué)報, 2014, 000(003):257-259.

2.  李季, 李凌軍, 婁華偉. 天鉤降壓膠囊中鉤藤堿、異鉤藤堿大鼠在體腸吸收動力學(xué)研究[J]. 中國實驗方劑學(xué)雜志, 2013, 19(6):167-170.

1.  婁華偉, 李凌軍, 李季. 天鉤降壓膠囊中鉤藤堿、異鉤藤堿在大鼠離體小腸的吸收動力學(xué)研究[J]. 中國實驗方劑學(xué)雜志, 2013, 19(7):150-153.